Open Science Abbreviations

General Abbreviations

This is a valuable site when looking up any NASA-specific acronyms: Acronym Central

OSDR: Open Science Data Repository
BDME: Biological Data Management Environment
GL: GeneLab
OSD: Open Science Dataset
GLDS: GeneLab DataSets
ALSDA: Ames Life Sciences Data Archive
NBISC: NASA Biological Institutional Scientific Collection
RDSA: Research Data Submission Agreement
LSDS: Life Science DataSets
DAR: Data Access Request
AWG: Analysis Working Group

Data Systems Abbreviations

MVP: Minimum Viable Product

Sample Abbreviations

FLT

spaceflight

GC

ground control for a spaceflight experiment - mimics the environmental conditions, timeline, and equipment used for the spaceflight samples

VIV

vivarium control for a spaceflight experiment - same timeline and subjects as the spaceflight experiment but housed under standard laboratory conditions

BSL

baseline (or basal) control for a spaceflight experiment - subjects from the same cohort as a spaceflight experiment that are processed at the start of a spaceflight experiment to establish the initial condition of the experimental subjects

pFLT

parabolic flight

pGC

ground control for parabolic flight (i.e. samples were grown/processed in the same equipment as those in the pFLT groups)

soFLT

suborbital ballistic rocket flight

soGC

ground control for suborbital ballistic rocket flight (i.e. samples were grown/processed in the same equipment as those in the soFLT groups)

CTRL

control group for a space-relevant (but NOT spaceflight) experiment

HLU

hind limb unloading (aka hindlimb suspension)

RL

re-loaded - subjects re-exposed to limb/body loading

HLLC

hind limb loaded control

TRHLLC

tail restrained hind limb loaded control

uG

microgravity

HG

hypergravity

1G

1x gravity

2G

2x gravity

act

activated

nonact

non-activated

Tcells

T cells

Dmel

Drosophila melanogaster

Can-S

Canton-Special (strain of Drosophila melanogaster)

Ecol

Escherichia coli

Bbas

Beauveria bassiana

infdw

infected with

uninfd

uninfected

sham-infd

sham infected, treated similarly to the infected group but administered a control solution that does not contain an infectious agent (i.e. treated with PBS, water, etc.)

Atha

Arabidopsis thaliana

Brap

Brassica rapa

nipp

nipposinica (variant of Brassica rapa)

Etsl

Etiolated seedlings

UdCC

undifferentiated cell culture

BA1

BRIC A PDFU-1

BA2

BRIC A PDFU-2

BA3

BRIC A PDFU-3

BA4

BRIC A PDFU-4

BA5

BRIC A PDFU-5

BB2

BRIC B PDFU-2

BB3

BRIC B PDFU-3

BB4

BRIC B PDFU-4

BB5

BRIC B PDFU-5

BG1

BRIC G PDFU-1

BG2

BRIC G PDFU-2

BG3

BRIC G PDFU-3

WT

wild-type

MUT

mutant

wo

whole organism

ADR

Adrenal Glands

AT

Adipose Tissue

BAT

Brown Adipose Tissue

BRN

Brain

Cb

Cerebellum

CEC

Cecum

CLN

Colon

DSKN

Dorsal Skin

EDL

Extensor Digitorum Longus

eWAT

Epididymal White Adipose Tissue

EYE

Eye

FCS

Feces

FSKN

Femoral Skin

GST

Gastrocnemius

HPC

Hippocampus

iBAT

Interscapular Brown Adipose Tissue

iWAT

Inguinal White Adipose Tissue

KDN

Kidney

LD

Longissimus Dorsi Muscle

Lg-INT

Large Intestines

LNG

Lung

LVR

Liver

HRT

Heart

INT

Intestines

MG

Mammary Gland

OVY

Ovary or Ovaries

Quad

Quadricep

RTN

Retina

SKN

Skin

SLS

Soleus

SM

Skeletal Muscle

SPL

Spleen

TA

Tibialis Anterior

TES

Testis or Testes

TIB

Tibia

TMS

Thymus

TNG

Tongue

WAT

White Adipose Tissue

RR

Rodent Research

MHU

Mouse Habitat Unit (JAXA mouse habitat unit)

FS

Freezing Study

JAXA

Japan Aerospace Exploration Agency

CC

Cohort Control

C#

Cohort Number

LAR

Live Animal Return

ISS-T

ISS Terminal Animal

NuRFB

Nutrient Upgraded Rodent Food Bar

IR

Irradiation

BSP

Biospecimen Sharing Program

LSDA

Life Science Data Archive

ACF

Animal Care Facility

LLU

Loma Linda University

KSC

Kennedy Space Center

RNA

Ribonucleic acid

DNA

Deoxyribonucleic acid

PRT

Protein

ALQ

Aliquot

LN2

Liquid nitrogen

RNAlat

RNA later

RIN

RNA integrity number

DIN

DNA integrity number

MIX1

ERCC Spike In mix 1

MIX2

ERCC Spike In mix 2

BLD

Blood - we may want to revisit this - Whole Blood (WB), White Blood Cells (WBCs), Red Blood Cells (RBCs)

WB

whole blood

WBCs

White Blood Cells

RBCs

Red Blood Cells

leu

Leukocytes

L

Left

Lg

Large

R

Right

D

Dorsal

V

Ventral

F

Femoral

OD

Optical Density

URR

Universal Reference RNA

UHRR

Universal Human Reference RNA

UMRR

Universal Mouse Reference RNA

Gspe

Genus species

C57-6J

C57BL/6 mouse from Jackson Labs

OR

Oregon R (Fruit Fly strain)

act2-3

Arabidopisis thaliana vegetative actin mutant

Col-0

Arabidopsis thaliana Columbia-0 ecotype

C57-10J

C57BL/10J mouse from Jackson Labs

Ler-0

Landsberg ecotype

sShoots

seedling shoots

C57-6IBCh

C57BL/6 mouse from Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russia

C57-6T

C57BL/6 mouse from Taconic Biosciences

I

dissected immediately after euthanasia

C

dissected from frozen carcass

ARG1-KO

thaliana Col-0 knock-out line deficient in the gene encoding Altered response to gravity-1

JkTcells

Jurkat T cells

C57-6CR

C57BL/6 mouse from Charles River

os-ind

osteo-induced

not-ind

not induced

BMSC

Bone Marrow Stromal Cells

MSCs

Mesenchymal Stem Cells

EMF

treated with electromagnetic fields

suG

simulated microgravity

LDC

Large Diameter Centrifuge

RPoM

Random Positioning Machine

ML

Magnetic Levitator

do

days old

yo

years old

oLDC

outside the Large Diameter Centrifuge

oRPoM

outside the Random Positioning Machine

oML

outside the Magnetic Levitator

YR

Gamma Radiation

HZE

High (H) Charge (Z) and Energy (E) HZE ionizing radiation

ATM1

mutant defective in the DSB-sensing protein kinase ATM

Gy

Gray

sl

seedling

sl-pool

pool of 2 or more whole seedlings

lvCMC

left ventricular cardiomyocytes

MCL

medial collateral ligament

Rnor

Rattus norvegicus

Sx

surgery

noSx

no surgery

shamSx

sham surgery

bildisMCL

bilateral disruption of the medial collateral ligament

lpup

late pupae

dT

delta (change in) Temperature

NOdT

no change in Temperature

ltdO2

limited Oxygen

normO2

normal Oxygen levels

Ws-0

Wassilewskija-0 (Arabidopsis thaliana) ecotype, species variant 391

Ws-2

Wassilewskija-2 (Arabidopsis thaliana) ecotype, species variant 393

Ws

Wassilewskija (Arabidopsis thaliana) ecotype, species variant 382

Cvi-0

Cape Verde Islands - 0 (Arabidopsis thaliana) ecotype, species variant 98

suppO2

supplemented with Oxygen

kPa

kilopascals

Hml-Gal4-UAS-GFP

Hemolectin-GAL4 crossed with UAS-GFP to make a transgenic line in Dmel

TKSC

Tsukuba Space Center (JAXA)

N2

Bristol N2 (C.elegans strain)

Clinorotation

Clinorotation

ISS

International Space Station

RWV

Rotating Wall Vessel

2T3cells

osteoblast cell line 2T3

LS292

C.elegans strain representing a dys1(cx18) mutant

HF

Hair Follicles

inFLT

in spaceflight (describes condition in which sample was collected)

preFLT

pre spaceflight (describes condition in which sample was collected)

postFLT

post spaceflight (describes condition in which sample was collected)

BAL-SL

BALB/c mouse from Simonsen Labs

BAL-JL

BALB/c mouse from Jackson Laboratory

BAL-TAL

BALB/c mouse from Taconic Animal Laboratory

4T1-Tumor

Flank tumor derived from the 4T1 murine mammary carcinoma cell line that was generated from a BALB/cfC3H mouse

1D11

Antibody that binds to TGFB and thus inhibits function

IsoCTRL

Isotype control - primary antibodies that lack specificity to the target, but match the class and type of the primary antibody used in the application

TGFB-Het

TGFBeta-Heterozygote

Sham

type of control sample

post-Sham

describes sample post sham

post-IR

describes sample post irradiation

wk

week (Time)

LCL

Lymphoblastoid Cell Line

GM15036

Lymphoblastoid Cell Line GM15036

GM15510

Lymphoblastoid Cell Line GM15510

RCCS

Rotary Cell Culture System

RAW2647cells

RAW 264.7 cell line

TK6cells

TK6 Lymphoblast Cell Line

cax1-1

describes cax1-1 transgenic line of Arabidopsis thaliana

SDR

Sprague Dawley Rats

SDR-TF

Sprague Dawley Rats from Taconic Farms

56Fe

Iron isotope

C3H-He-Slc

C3H/He mice from Japan Slc, Inc.

C57-6J-Jms-Slc

C57BL/6J Jms mice from Japan Slc, Inc.

AJ-Jms-Slc

A/J Jms mice from Japan Slc, Inc

h

hour (Time)

Cs137

Caesium-137 isotope

Epi200MT

3-dimensional tissue model of human epidermis, MatTek Corporation, Ashland, MA

SMK

Smoker - not to be confused with Super Mario Kart

nSMK

non-Smoker

um

micrometer

tumor

tumor

MCF10Acells

MCF10A cells - human mammary epithelial cells

TGFB

Tumor Growth Factor Beta

X-ray

X-ray irradiation

Preg

Pregnant

Lac

Lactating

Hi-LET

High Linear Energy Transfer

Si

Silicon isotope

C3H-HeJ

C3H Heston mouse from Jackson Labs (aka C3H/HeJ)

d

day (time)

K-12MG1655

strain (of E. coli) K-12 MG1655

HBF

hyper-buoyancy flotation (used for bed-rest study)

VL

vastus lateralis

Rep

replicate

Hsap

Homo sapiens

Mmus

Mus musculus

shamIR

mock irradiation (i.e. subject to irradiation equipment but not exposed to irradiation)

HUVEC

Cells derived from the endothelium of veins from the umbilical cord

Scer

Saccharomyces cerevisiae

BY4742

Strain of Saccharomyces cerevisiae

BY4742_FLO1

cerevisiae strain BY4742 over-expressing the FLO1 member of the Flo adhesin protein family

BY4742_FLO8

cerevisiae strain BY4742 over-expressing the FLO8 member of the Flo adhesin protein family

Cele

Caenorhabditis elegans

BMCs

bone marrow cells

BM

bone marrow

Euth

Euthasol

DI

Dry Ice

Ket-Xyl

Ketamine/Xylazine

ext1

RNA was extracted the same day organs were dissected from frozen carcasses

ext2

Organs were dissected from frozen carcasses, flash frozen in (l)N2 and stored at -80C then RNA was extracted on a later date

Lminus

Launch minus (usually followed by a time frame, for example Lminus30d means 30 days before launch)

Lplus

Launch plus (usually followed by a time frame, for example Lplus30d means 30 days after launch)

Rminus

Return minus (usually followed by a time frame, for example Rminus30d means 30 days before return to earth)

Rplus

Return plus (usually followed by a time frame, for example Rplus30d means 30 days after return to earth)

CO2

Carbon Dioxide

RLT

RNeasy Lysis Buffer

IRC

Irradiation Control - No mock IR was performed, i.e. subjects were not exposed to IR nor an IR set-up

F#

mouse number from a spaceflight group

G#

mouse number from a ground control group

B#

mouse number from a basal group

V#

mouse number from a vivarium group

R1

Forward Read

R2

Reverse Read

JC

JAXA Chow

JCwFOS

JAXA Chow fortified with fructooligosaccharides (FOS)

Alight

specimen grown in Ambient light

dark

specimen grown in darkness

Col-0-PhyD

Columbia ecotype with a mutation in phytochrome D (PhyD)

mon

month

y

year(s)

SP

spleen pool - spleens from 2 or more animals pooled together to make one sample

ss-tissues

tissues that underwent size selection during library prep (after extraction)

tissues

more than 1 tissue from 1 animal was pooled

MCC

MidiCAR centrifuge

MgSO4

magnesium sulfate

min

minute

Rotation

rotation

Hypocotyl

hypocotyl

HypocotylCC

Hypocotyl cell culture (a cell culture derived from the hypocotyl part of the plant)

PBLD

Peripheral Blood

In-FLT-CTRL

In-flight Control

PC

pipette centrifuge

Olat

Oryzias latipes

TGFP-ODsRed

Oryzias latipes (Japanese medaka) F1 fish of two closed colonies; Japanese medaka wild type Cab and Cab strain transgenic fish (TRAP:GFP, Osterix:DsRed)

NCTC-86

strain (of E. coli) NCTC 86; ATCC 4157

ug-mL

concentration in micrograms per milliliter

Smut

Streptococcus mutans

ITS

internal transcribed spacer

Paer

Pseudomonas aeruginosa

RWV-V

Rotating Wall Vessel in vertical direction

RWV-H

Rotating Wall Vessel in horizontal direction

PA01

PAO1 strain - Pseudomonas aeruginosa

HMVEC-dBL

Human dermal microvascular endothelial cells

LPS

lipopolysaccharide

S-UHRR

Stratagene Universal Human Reference RNA

PTN-OSF1

transgenic mice overexpressing the osteogenic factor PTN/OSF1

cells

material type - cell line

DLD-1

DLD-1 cells epithelial, adherent cell line derived from a colorectal adenocarcinoma (Dukes type C)

MOLT-4

MOLT-4 cell line T lymphoblast, suspension cell line derived from an acute lymphoblastic leukemia

IMR90iPSCs

induced pluripotent stem cells derived from the IMR90 human cell line

CPCs

Cardiac progenitor cells

PhaB

Pharyngeal Bones

Cab

wild type Cab strain of Oryzias latipes (Japanese medaka fish)

LC

Laboratory control - may refer to a control group or groups grown under standard laboratory conditions and processed to test an aspect(s) of spaceflight experimental parameters

TLCs

T lymphocyte cells

cGy

centigray

168

Strain of Bacillus subtilis

PBMCs

peripheral blood mononuclear cells

pip2Dclino

2D pipette clinostat

pipcent

pipette centrifuge

ALLCL

acute lymphoblastic leukemia cell line

CRCCL

colorectal cancer cell line

GF

Glovebox Freezer

CyroC

Cyrochiller

WCar

Whole Carcass (i.e. the sample was extracted from an intact carcass)

PCar

Partial Carcass (i.e. the sample was extracted from a carcass that had one or more part(s) removed)

Esco

Euprymna scolopes

aposym

aposymbiotic

sym

symbiotic

HARV

high-aspect-ratio rotating wall vessel bioreactors

LO

Light Organ

UAMS-1

Strain of Staphylococcus aureus

Saur

Staphylococcus aureus

Mmar

Mycobacterium marinum

LHM4

Strain of Mycobacterium marinum

InsP-5-ptase

transgenic Arabidopsis thaliana (Columbia-0) plants constitutively express the mammalian type I inositol polyphosphate 5-phosphatase (InsP 5-ptase)

LLC

Lewis lung carcinoma

LLCtumor

Tumor derived from Lewis lung carcinoma cells

LLCcells

Lewis lung carcinoma cells

Trp53N-MG

Trp53 null mammary gland

B6.129S2KrasLA1

B6.129S2-Kras^tm2Tyj^/Nci Mouse strain - This strain carries a targeted latent ‘hit-and-run’ K-ras allele that can be activated by an in vivo spontaneous recombination event (‘run’). One half of the in vivo recombination events result in a normal K-ras allele and one half in an activated allele (K-rasG12D).

Trp53N-MGT

Trp53 null mammary gland tumor

Drer

Danio rerio

PBLs

peripheral blood lymphocytes

AG01522

human fibroblasts AG01522 cells

ble

bleomycin

FBC

fibroblasts cells

Low-LET

Low Linear Energy Transfer

C57-6

C57BL/6 mouse from an unknown origin

cls

plant callus

T

tesla (magnetic field unit)

MM2d

Arabidopsis thaliana MM2d cell line

Bsub

Bacillus subtilis

S288C

strain of Saccharomyces cerevisiae

HIR

Heavy Ion Radiation

TNR

Thermal Neutron Radiation

FNR

Fast Neutron Radiation

HSFA2-KO

a knockout Arabidopsis thaliana line deficient in the gene encoding HSFA2

AB

Strain of Danio rerio

WN624

Strain of Bacillus subtilis

WN1106

Strain of Bacillus subtilis

HEBC3KT

a human bronchial epithelial cell line

28Si

Si 28 isotope

Zone-I

region of root apex: 0.5 mm, root cap and meristematic zone

Zone-II

region of root apex: 1.5 mm, transition, elongation and growth terminating zone

Node3

node 3 of ISS

AHSFS

air handling system filter screen of ISS

SIEV

sieved

Batr

Bacillus atrophaeus

blank

no DNA or RNA added to extraction kit

PAS

passive aerosol sample

HBECs

human bronchial epithelial cells

2D

cells grown in 2D condition

3D

cells grown in 3D condition

TT

tetanus toxoid (treatment with tetanus toxoid)

noTT

tetanus toxoid control (animals were not treated with tetanus toxoid, just the solution used to dilute the tetanus toxoid)

ODNCpG

adjuvant treatment of a synthetic oligodeoxynucleotide (ODN) containing unmethylated CpG motifs (CpG)

noODNCpG

adjuvant treatment control (animals were not treated with ODNCpG, just the solution used to dilute the ODNCpG)

AG1522

a normal human foreskin fibroblast cell line

HT1080

a human fibrosarcoma cell line

RAD51

RAD51 gene

G1

G1 phase of cell cycle

G2

G2 phase of cell cycle

Asyn

Asynchronous cells, cells in various phases of cell cycle

FirstSet

first set of animals (or samples) processed/preserved in a given day of operations

SecondSet

second set of animals (or samples) processed/preserved in a given day of operations

ThirdSet

third set of animals (or samples) processed/preserved in a given day of operations

FourthSet

fourth set of animals (or samples) processed/preserved in a given day of operations

CTRLSet

control set of animals (or samples) processed/preserved in a given day of operations

Styp

Salmonella typhimurium

SL1344

Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344

dhfq

isogenic hfq deletion mutant

HT-29

human colorectal adenocarcinoma cell line with epithelial morphology

U937

human macrophage cell line established from a diffuse histiocytic lymphoma

3DCoC

3D co-culture model

LoopG

Loop Genomics

w1118

strain of Drosophila melanogaster

16S

16S rRNA gene

DFVS

dust filter of ventilation system

VAC

vacuum

INCd

incubated

arch

archaea

uni

universal

M#

mouse number

S#

subject number

scWim

sample collected while inside module

scAem

sample collected after exiting module

scBem

sample collected before entering module

SKF

ion channel inhibitor SKF-96365

HRremoved

Human Reads removed

Heat

samples treated with heat

noHeat

samples not treated with heat

Anox

Anoxia (oxygen deprived)

noAnox

not Anoxia (not oxygen deprived)

mid-age

middle-age

C57-6NIA

C57BL/6 mouse from National Institute of Aging

CUMS

chronic unpredictable mild stressors

Eves

Eruca vesicaria

CAAT

Controlled Artificial Ageing Treatment

cop1

cop1 gene

uvr8

uvr8 gene

PWB

partial weight bearing, as with a harness to reduce loading on all limbs - usually followed by a value for the % of loading. Ex: PWB40 = 40% of normal loading; PWB100 = 100% of loading (or loading control)

FEM

femur

TRIB

triceps brachii

CVA

calvaria

GIS

Genes in Space (payload)

RR-4_ShF#-W

Mouse number # from payload RR-4 which underwent spaceflight (F) and a sham (Sh) surgical procedure where bone defects were filled by the bioabsorbable scaffold imbued with saline as a control. The whole body (W) was frozen and preserved on ISS.

RR-4_ShG#-L

Mouse number # from payload RR-4 from the ground control (G) group which underwent a sham (Sh) surgical procedure where bone defects were filled by the bioabsorbable scaffold imbued with saline as a control. The leg (L) was dissected from the carcass on ISS before the rest of the carcass was frozen.

RR-4_ShV#-W

Mouse number # from payload RR-4 from Vivarium Control (V) group which underwent a sham (Sh) surgical procedure where bone defects were filled by the bioabsorbable scaffold imbued with saline as a control. The whole body (W) was frozen and preserved on ISS.

RR-4_NSB#-L

Mouse number # from payload RR-4 from the baseline control (B) group which underwent no surgical (NS) as a control group. The leg (L) was dissected from the carcass on ISS before the rest of the carcass was frozen.

RR-4_BMP_F#

Mouse number # from payload RR-4 which underwent spaceflight (F) and a surgical procedure where bone defects were filled by similar bioabsorbable scaffold imbued with bone morphogenic protein-2 (BMP-2).

RR-4_TPO_G#

Mouse number # from payload RR-4 from the ground control (G) group which underwent a surgical procedure where bone defects are filled with a novel bioabsorbable scaffold imbued with thrombopoietin (TPO).